Also on Tuesday, men's seventh seed Matteo Berrettini of Italy cruised to a 6-3, 6-1, 6-3 victory over Canadian Vasek Pospisi.
Both are very much underdogs against Manchester United, Paris Saint-Germain and Istanbul Basaksehir (Leipzig) and Real Madrid, Inter Milan, and Shakhtar Donetsk (Gladbach).
Hoffenheim then grabbed the lead out of the blue with 16 minutes gone when Ermin Bicakcic headed home Dennis Geiger's corner kick to stun Hansi Flick's men.
The hosts dominated early as Jorge Recalde scored either side of a Carlos Sanchez penalty at the Manuel Ferreira stadium in Paraguayan capital Asuncion.
SUZHOU, China, Sept. 28 (Xinhua) -- The Chinese Super League (CSL) wrapped up its first stage here on Monday with Guangzhou Evergrande leading the top eight teams into the second stage slated to kick off on October 16.
"It's important for a striker to score goals," said Icardi. "Today we lacked the efficiency to kill the match earlier, but we are happy with the result."
Eight international ice makers from Russia, France, Canada and other countries and regions participated in the ice making work along with 20 domestic ice makers which construct the first ice making and repairing team in China.
Mendilibar lost several key players, such as Fabio Orellana, Charles and Escalante over the summer, while Ivan Ramis retired, and so far adequate replacements haven't arrived leaving the squad weaker than the one which struggled last season.
Willy Caballero replaced Kepa in the Chelsea goal, but had picked the ball out of his net three times by the 27th minute as Callum Robinson scored twice and Kyle Bartley made it 3-0.
Real Sociedad ruined Elche's return to the top flight as they won 3-0 in Elche's Martin Valero stadium with second half goals from Portu, Adnan Januzaj and Roberto Lopez.
PARIS, Sept. 30 (Xinhua) -- Tenth-seeded Victoria Azarenka saw her campaign at Roland Garros end on Wednesday as the Belarusian was shocked by former world No. 26 Anna Karolina Schmiedlova of Slovakia 6-2, 6-2 in a match where she racked up 36 unforced errors.